Infamous: Second Son is starring a brand new protagonist, but that's not the only change coming to the franchise for its first PlayStation 4 outing. A brochure implies that the game may get some form of multiplayer mode, which if true, would be a series first.
Videogamer reports that a PlayStation 4 brochure offline single-player, and then "online players TBC" (aka "To Be Confirmed"). Other single-player games in the brochure, like Knack, reportedly don't include such a listing. That indicates that the wording was slipped into the Second Son entry for a reason.
This is speculative for the time being, and Shacknews has contacted Sony to confirm. We'll update as more information becomes available.