The Zone of the Enders HD Collection will include its sequel, 2nd Runner Special Edition. Series creator Hideo Kojima revealed the inclusion, marking the first time the SE content will be available in North America.
A photo tweet from Kojima (via Siliconera) shows the menu selection for "Anubis," which was 2nd Runner's title in Japan. The Special Edition packs additional difficulty modes, missions, and cutscenes. Previously, only the standard 2nd Runner was available in North America, so this should make the package a nice treat for series fans.
The Zone of the Enders HD Collection is due sometime in 2012.