"Since we develop primarily on PC, you won't see any compromises in the PC version," the developer said. "The key difference between the PC and console versions will be the beauty of graphics (meaning PC will offer more of visual effects)." GSC also insisted that the user interface on PC won't be harmed by multiplatform development.
Summing up what's new, GSC said "In brief, S.T.A.L.K.E.R. 2 will offer new story, new set characters (with some good old ones) and, of course, the new engine powering it." That new engine will use shiny DirectX 11. There'll also be more of a survival element.
GSC further revealed that "We'll be locating the game in the triangle of CNPP, the cities of Chernobyl and Chernobyl 2 (where the huge antenna is located)."
S.T.A.L.K.E.R. 2 is slated for release in 2012, hitting PC and unconfirmed consoles; Xbox 360 and PlayStation 3 seem the most likely targets.