nope Edmund McMillen, one of the two-man development team, told Eurogamer that "there will be another game but it won't be Meat Boy. It'll be totally new."
It might be a while before work on the next game begins, however, as "thinking about it right now makes me want to stab myself in the stomach as hard as I can," explains McMillen after 18-months of development on Super Meat Boy. "With a gun."
The PC version will also add Mr. Minecraft when it is released next month.