Some people may not be aware of this, but Legend Entertainment is working on the sequel to Unreal (Not Epic). The working (and mysterious) title for the sequel to Unreal is tentatively being called Unreal2. Aaron Leiby of Legend has this to say about the sequel:

Unreal2 will be the sequel to Unreal1 (not Unreal Tournament), and it will not pick up where either Unreal1 or Return to NaPali left off. As such, its primary focus will be on the single player experience. We are planning to include some multiplayer aspects which will mostly evolve out of the story.

In addition to that, it looks like the design choices have already been made as level design Matt Worch (aka that wacky German dude) states on the UT messageboards that the Unreal2 design has been done since before the release of UT. Matt continues by saying that Legend is taking the same route as 3DRealms in choosing not to reveal information about the game