Not to gloat or anything, but in regards to GTAV, one of the things the developers said in the GI preview was that there would be a lot less side characters, or "mission givers" because of the zapping system they're introducing, and that pretty much coincides exactly with my line of criticism against RE6's co-op design. The more you have dead "game" characters, the more you hurt the narrative and design of the campaign. They said that because they have to constantly keep track of these 3 protagonists, the protagonists themselves tend to propel the thrust of the missions and narrative. As a result, not only will the story be more coherent, but they're going to be designing much more elaborate heist style missions (ie bank robbing)---which is exactly what I loved about GTAIV.
I will say I'm a little bit disappointed that none of the protagonists will be women. I'm still hoping for a GTA stripper protagonist with a colored past who gets into organised crime on the side. All in all though GTA has become one of the only long running franchises left in this industry that has any credibility with its critical audience. Every successive title in the franchise has featured major advancements creatively and technically. They're also one of the few remaining standard bearers of the single player campaign as a major show case for the medium. So, basically I am super excited for the game. It seems like fall is rapidly becoming the feeding ground for mega giant franchises kind of repeat the same thing every year, and Q1-Q3 is where all the interesting stuff is landing.