What Would make resident evil better setting. Look at left for dead you have a creepy farmhouse, a great tunnel chase, a epic battle on top of a skyscraper. What are the best resident evil one and two setting wise a lonely mansion, a police station it's been decimated by zombies. thats a creepy air tension the helps completely gone you have nothing to rely on.
Next you need a Jurassic park styles story where the madmen in charge are at Civil War with each other. The civi war that's basically unlocked the prisoners to roam free and there's no ability or no one put them back in their cage.
And then just a combat mechanic that creates tension. Like say having to reload each bullet in the shotgun one time and it taking almost a real world like time.