I have been playing this hardcore over the last week on my 360 installed to the hard drive. Load times are longer than I wish they were, but have not diminished my interest in the game. Im still excited to arrive in the new location and accomplish my goal there. Not a single crash and the only "bug" I saw was were a character who was supposed to spawn on a bar stool, spawned in the bar. Looked funny. No issues with progression.

I like everything that I liked about Fallout 3, being here but more of it and with nice tweaks.
I like the companion system, though maybe I was lucky and picked up two who really help my play style.
I like upgrading my weapons, and having ammo choices based on the situation.

I dont like the fact that a silenced rifle shot from range that alerts no one to my presence affects my reputation with the faction I just stuck a bullet into. Though I understand why it happens.
I dont like the fact that I can kill a member of a faction in their "town", and gain Karma ( they were bad men! ), loot their body, but I cant pick up the stimpack on the table next to them without losing karma, because that would be stealing ..

My vote if you liked Fallout, get this.
If you like big expansive RPGs, get this.
If you like post-apocalyptic shooters, get this.