Being an owner of the PS3 version of DMC4 I was curious how well it translated to the PC, so I gave this a go. My impressions after playing it for a few minutes:

The good:
- Looks and runs fantastic. Frame rate was always over 60fps with everything on Super High and C8x anti-aliasing. Higher resolution, anti-aliasing, and sharper textures make it looks better than its PS3 counter-part.
- Load times are very fast. Faster than on the PS3 (which, remember, has an install).
- Menus can be controlled with a mouse and there's a proper PC config menu. Kind of sad this point has to be made but many bad ports seem to miss this important point.
- Benchmark tool. Neat.

The bad:
- I don't own a decent controller so I tried to play using the keyboard. Terrible. This game must be played using a game pad, preferably a 360 controller or something with similar layout to the PS3 controller (depends on personal preference). Buttons can be remapped, which is good, but without analog sticks and shoulder buttons you will probably find that your fingers are quite cramped. Note that the game seems to want you to use a 360 controller since the menus and instructions are given using those icons.

All things considered (within 10 minutes of playtime, hehe), this seems to be a strong port. Just be sure to have proper controller ready. I worry that it won't sell well, since everyone who wants to play has probably already done so on another system.