The notoriously buggy launch of The Elder Scrolls V: Skyrim was mended somewhat by the 1.2 patch, but reports from users claim that the patch introduced new glitches to the game. Most prevalent seems to be a bug with resistance effects, doling out full damage to special attacks no matter what protection you have.
A thread on the Bethesda forum (via Eurogamer) summarizes the common complaints post-1.2. In addition to the resistance effects, users claim that platform specific bugs like frame-rate issues and texture loading still persist. If you can find some humor in the situation, the forums also have multiple reports of dragons flying backwards.