Traditionally, Link from the Legend of Zelda series has been left-handed. But the majority of the population is right-handed. Because you'll be swinging your controller like a sword in Skyward Sword, Nintendo has turned Link into a rightie. As it turns out, The Legend of Zelda: Skyward Sword won't have a left-handed option, so southpaws will just have to adapt.
Nintendo confirmed the righties-only control scheme to Kotaku. Writer Stephen Totilo assures that his time with the game as a left-handed person was a bit difficult at first, but he got used to it. Nintendo had previously mentioned a left-handed mode to IGN, but plans must have changed.
Perhaps the game would have been more welcoming to left-handed players, had it stayed true to its original "buttons-only" gameplay. Siliconera reports that lead designer Ryuji Kobayashi was finalizing the button-based battle controls when producer Eiji Aonuma changed plan to Wii MotionPlus. Aonuma had been convinced by the fencing and archery games in Wii Sports Resort, which shifted the game's focus to 1:1 motion controls.
Skyward Sword will be available on Wii on November 20th.