"We have and had an amazing design for the Ender's Game game," Chair co-founder Donald Mustard told Joystiq. Unfortunately, he explained that "one of Epic's primary objectives is to create original and unique franchises. I don't know that Ender's Game fits into that strategic objective anymore."
"So, probably not," Mustard said of the game coming to fruition. "Not from us."
Chair, developer of Shadow Complex--itself based up another of Card's novels--and Unreal Engine 3-powered iPhone game Infinity Blade, was acquired by Epic Games in May 2008, several months after the Ender's Game announcement.
Should you not be expecting plot details from a quarter-century-old book, whose secrets are widely-discussed, to be in a post related to that book, you might want to stop reading at this sentence. Because: while Epic may not be interested in letting you play a child who is unaware that his games are in fact part of a real war, luckily it's still more than happy to let you play as a manchild who sees war as one jolly big game.