According to USA Today, bustin' will continue in Ghostbusters: Sanctum of Slime. The top-down action title features four-player online and offline co-op, the ability to drive the Ecto-3 at some point, and puts players back in the shoes of "the rookie" from Terminal Reality and Red Fly Studios' 2009 Ghostbusters title.
Sadly, the original Ghostbusters crew will not reprise their roles for the game and it's unclear whether the original team will even be in the downloadable title at all. It seems like a real "passing of the guard" situation, to which we say "kindly pass it back."
Ghostbusters: Sanctum of Slime is being developed by Wanako Studios, the team that recently launched 3D Ultra Minigolf Adventures 2, and is expected to hit the PC, XBLA, and PSN next spring.