Dead Space's mute protagonist Isaac Clarke will return in the sequel with "new tools to gruesomely slice and dismember," and new supporting characters as he "[takes] the fight to the Necromorphs" and apparently "this time, he calls the shots." nope
"The infection continues to spread throughout space and our hero Isaac Clarke is the only person able to contain it. There are still loads of Necromorphs that need killing," explained executive producer Steve Papoutsis in a press statement. "In Dead Space 2, not everything is exactly as it seems. Expect plot twists that will surprise you and a huge cast of twisted, disgusting monsters that are sure to scare the daylights out of you."
Dead Space 2 is under development for PC, Xbox 360 and PlayStation 3, with no mention made of a release date. Visceral Games is currently working on the bizarre action allegory Dante's Inferno and a Dead Space movie is also in the pipeline.