Titled Call of Juarez: Bound in Blood, the game takes place before the original, with Techland once again developing. Locations vary from "a ravaged Civil War-era Georgia to the Aztec ruins of Mexico," with Ubisoft promising "the wildest West ever depicted." A render of the game, above, was also released.

The announcement further specified that "players can embody both McCall brothers" across the story, suggesting the possibility of a co-op campaign.

The original, which hit PC in 2006 and Xbox 360 in 2007, featured competitive and cooperative multiplayer modes, but did not allow co-op play of the main campaign.