Titled Castlevania Judgment and due out this fall, the game is said to pit several generations of the vampire-slaying Belmont family against their numerous foes in 3D combat, complete with motion-sensing controls and online multiplayer.
"This combination is certain to thrill old and new fans of the franchise," said Konami marketing VP Anthony Crouts.
Few details were provided, though players will be able to make use of environmental weapons in addition to the series' usual whips and swords. Certain characters will be able to set traps on the battlefield and "make use of monsters."
The title will sport connectivity with the upcoming traditional DS entry, Castlevania: Order of Ecclesia, to unlock unspecified "bonus gameplay content."
Producer Koji "Iga" Igarashi, who has watched over the Castlevania series since Symphony of the Night (PSX) in 1997, is heavily involved in the project, with character designs provided by Death Note manga artist Takeshi Obata.
"We wanted to take this addition to the signature Konami franchise in a direction that really sets it apart from the previous Castlevania titles in the series," added Crouts. "The Wii Remote and Nunchuk capabilities, along with the iconic characters, make this game the ideal entry point into the fighting game genre."